In xenopus laevis and xenopus tropicalis, the gene pard6g encodes a scaffolding protein containing a PDZ domain. The protein localizes to the cytoplasm and cell membrane. It functions in establishing a...[+]

In xenopus laevis and xenopus tropicalis, the gene pard6g encodes a scaffolding protein containing a PDZ domain. The protein localizes to the cytoplasm and cell membrane. It functions in establishing apical-basal polarity during embryogenesis, particularly within the epidermis and neural tube. Its role involves forming a complex with other proteins to regulate the asymmetric division of neuroepithelial cells and is necessary for proper neural tube closure. [-]

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