The cul3 protein is a cullin-ring E3 ubiquitin ligase scaffold involved in proteasomal degradation by targeting specific substrates for polyubiquitination. It localizes to the nucleus and cytoplasm. Du...[+]

The cul3 protein is a cullin-ring E3 ubiquitin ligase scaffold involved in proteasomal degradation by targeting specific substrates for polyubiquitination. It localizes to the nucleus and cytoplasm. During embryogenesis, it is implicated in regulating convergent extension movements, neural crest development, and pronephros formation. Its function is associated with processes in the blastula, gastrula, neurula, and tailbud stages, interacting with proteins like klhl12 and affecting the notochord. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD