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XB-GENEPAGE-1221136
Gene Symbol:
invs
Gene Name: inversin
Synonyms:
NPH2
,
NPHP2
,
inversin
,
nephrocystin-2
,
invs-a
,
invs-b
( Gene Function: multiple ankyrin domains and two IQ calmodulin-binding domains: functions in cilia formation and left-right axis establishment Protein Function
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Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting...[+]
Interactants:
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Diseases: Disease Ontology:
Senior-Loken syndrome
OMIM:
NEPHRONOPHTHISIS 2; NPHP2
External Links:
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Xenbase Gene ID | XB-GENE-1221137 | XB-GENE-6255451 | XB-GENE-1221139 | |||||
Gene Symbol | invs | invs.L | invs.S | Chromosome | Chr8 | Scaffold36 | chr8S | |
Molecules | X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genomic Sequence |
Version 10.0
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Version 9.1
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Version 9.1
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CDS |
Gene model
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Gene model
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Gene model
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Entrez Gene |
100487895
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398717
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378491
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mRNA |
NCBI Nucleotide
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NCBI Nucleotide
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NCBI Nucleotide
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Protein
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Genomic |
X. tropicalis | X. laevis.L | X. laevis.S | |||||
Genome Browser (Click image to open in Genome Browser) |
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Genomic Synteny | Genomicus PANTHER | |||||||
Expression | Development Stages | Embryonic Tissues | Adult Tissues | |||||
Summary for |
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More Information |
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Data Mining | X. tropicalis | X. laevis.L | X. laevis.S | |||||
XenMine | invs | invs.L | invs.S | |||||
Orthology |
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mouse |
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rat |
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zebrafish |
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chicken |
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fruit fly |
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worm |
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Publications | ||||||||
First |
The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin., Hum Genet 2002 |
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Most Recent |
The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development., J Biol Chem 2018 ![]() |
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All | View All Papers 1 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology | |||||||
Functional Ontologies | X. tropicalis | X. laevis.L | X. laevis.S | |||||
GO | 11 terms | 5 terms | 5 terms | |||||
PANTHER | invs | |||||||
KEGG Pathways | K19626 | K19626 | K19626 | |||||
KOG |
[R] FOG: Ankyrin repeat
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Reagents | X. tropicalis | X. laevis.L | X. laevis.S | |||||
CRISPRscan Tracks | invs | |||||||
Antibodies | Invs Ab1 | Invs Ab1 | Invs Ab1 | |||||
Morpholinos | invs MO1 | invs MO1 | invs MO1 | |||||
Clones | Horizon Source BioScience | Horizon Source BioScience | Horizon Source BioScience | |||||
Plasmids | Addgene | Addgene |
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