Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (17) GO Terms (5) Nucleotides (59) Proteins (35) Interactants (184) Wiki
XB-GENEPAGE-1221136
Gene Symbol :
invs

Gene Name :
inversin

Synonyms:
NPH2 , NPHP2 , inversin , nephrocystin-2 , invs-a , invs-b [+] ( Add synonyms , Nomenclature history )

Gene Function:
multiple ankyrin domains and two IQ calmodulin-binding domains: functions in cilia formation and left-right axis establishment

Protein Function :
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting...[+]


InterPro :
CNKSR2 , SAM , PDZ , PDZ sf [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Senior-Loken syndrome [+]

OMIM:
NEPHRONOPHTHISIS 2; NPHP2

External Links:
 
Expression                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: Single cell: RNA-Seq:

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info