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Summary Expression Gene Literature (207) GO Terms (15) Nucleotides (57) Proteins (34) Interactants (178) Wiki
XB-GENEPAGE-1221136
Gene Symbol:
invs

Gene Name:
inversin

Synonyms:
NPH2 , NPHP2 , inversin , nephrocystin-2 , invs-a , invs-b ( Add synonyms , Nomenclature history )

Gene Function:
multiple ankyrin domains and two IQ calmodulin-binding domains: functions in cilia formation and left-right axis establishment

Protein Function :
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting...[+]


InterPro :
CNKSR2 , SAM , PDZ , PDZ sf [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
Senior-Loken syndrome [+]

OMIM:
NEPHRONOPHTHISIS 2; NPHP2

External Links:
 
Xenbase Gene ID XB-GENE-1221137 XB-GENE-6255451 XB-GENE-1221139
Gene Symbol invs invs.L invs.S
Chromosome Chr8 Scaffold36 chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100487895
398717
378491
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine invs invs.L invs.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards INVS OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Invs MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Invs Ensembl
zebrafish
ZFIN, AGR invs ZFIN Ensembl
chicken
GEISHA INVS Ensembl
fruit fly
worm
Publications
First The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin., Hum Genet 2002  
Most Recent The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development., J Biol Chem 2018              
All View All Papers 1 paper(s) referencing morpholinos 4 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 11 terms 5 terms 5 terms
PANTHER invs
KEGG Pathways K19626 K19626 K19626
KOG [R] FOG: Ankyrin repeat
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks invs
Antibodies Invs Ab1 Invs Ab1 Invs Ab1
Morpholinos invs MO1 invs MO1 invs MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info   [+] Expand list