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Summary Expression Gene Literature (63) GO Terms (12) Nucleotides (171) Proteins (39) Interactants (1312) Wiki
Gene Symbol:

Gene Name:
frizzled class receptor 8

Xfz8 , Fz-8 , frizzled-8 , frizzled 8 , frizzled8 , fzd8-a , fzd8-b , fz8 ( Add synonyms , Nomenclature history )

Gene Function:
transmembrane receptor in the Wnt signaling pathway

Protein Function :
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nucl...[+]

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External Links:
Xenbase Gene ID XB-GENE-480800 XB-GENE-865411 XB-GENE-6254029
Gene Symbol fzd8 fzd8.L fzd8.S
Chromosome Chr6 chr6L chr6S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038274
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine fzd8 fzd8.L fzd8.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tneu087g20      
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC, AGR, Monarch, OMIM, GeneCards FZD8 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Fzd8 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Fzd8 Ensembl
ZFIN, AGR ZFIN, AGR fzd8a fzd8b ZFIN Ensembl
fruit fly
First A role for Xenopus Frizzled 8 in dorsal development., Mech Dev 1998    
Most Recent eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled., J Biol Chem 2020            
All View All Papers 8 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 10 terms 6 terms 7 terms
KEGG Pathways K02375 K02375 K02375
KOG [T] Smoothened and related G-protein-coupled receptors
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks fzd8
Morpholinos fzd8 MO4 fzd8 MO1 , fzd8 MO2 fzd8 MO2 , fzd8 MO3
ORFs fzd8 ORF1
Clones Horizon Source BioScience Horizon Source BioScience EXRC Horizon Source BioScience
Plasmids Addgene Addgene

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