Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (84) GO Terms (26) Nucleotides (52) Proteins (29) Interactants (504) Wiki
XB-GENEPAGE-483330
Gene Symbol:
pdx1

Gene Name:
pancreatic and duodenal homeobox 1

Synonyms:
ipf1 , XlHbox8 , pdx-1 , XlHbox-8 , STF-1 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Acts together with ptf1a to induce the pancreatic lineage within the endoderm.


InterPro :
dDENN dom , DENND1A/B/C , Tripartite DENN , cDENN dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
maturity-onset diabetes of the young [+]

OMIM:
TYPE 2 DIABETES MELLITUS; T2D [+]

External Links:
 
Xenbase Gene ID XB-GENE-483331 XB-GENE-17343771 XB-GENE-6464311
Gene Symbol pdx1 pdx1.L pdx1.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100490648
108708702
100337610
mRNA NCBI Nucleotide NCBI Nucleotide RefSeq
Protein NCBI Protein NCBI Protein TrEMBL RefSeq Swiss-Prot
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine pdx1 pdx1.L pdx1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards PDX1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Pdx1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Pdx1 Ensembl
zebrafish
ZFIN, AGR pdx1 ZFIN Ensembl
chicken
GEISHA PDX1 Ensembl
fruit fly
worm
Publications
First XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm., Development 1989            
Most Recent Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., Peptides 2021  
All View All Papers 14 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 5 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 23 terms 5 terms 6 terms
PANTHER pdx1
KEGG Pathways K07594 K07594 K07594
KOG [R] Transcription factor zerknullt and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks pdx1
Antibodies Pdx1 Ab1 , Pdx1 Ab2 Pdx1 Ab1 , Pdx1 Ab2
Morpholinos (on-target & off-target) pdx1 MO1 pdx1 MO1
Clones Horizon Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info