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Summary Expression Gene Literature (239) GO Terms (29) Nucleotides (116) Proteins (47) Interactants (923) Wiki
Gene Symbol:

Gene Name:
NK2 homeobox 5

tinman , csx , XNkx-2.5 , Nkx-2.5 , nkx2.5 , XNkx2-5 , nkx-2.5 , AR2 , nkx2-5-a , nkx2-5-b ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor with role in cardiac development

Protein Function :
Implicated in commitment to and/or differentiation of the myocardial lineage. May regulate the expression of genes involved in cardiogenesis and play a role in the formation of gut and the pharyngeal r...[+]

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Disease Ontology:
familial atrial fibrillation [+]


External Links:
Xenbase Gene ID XB-GENE-487966 XB-GENE-6464336 XB-GENE-865753
Gene Symbol nkx2-5 nkx2-5.L nkx2-5.S
Chromosome Chr3 chr3L chr3S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.2 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100144646
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine nkx2-5 nkx2-5.L nkx2-5.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC, AGR, Monarch, OMIM, GeneCards NKX2-5 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Nkx2-5 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Nkx2-5 Ensembl
ZFIN, AGR nkx2.5 ZFIN Ensembl
GEISHA NKX2-5 Ensembl
fruit fly
First XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development., Dev Biol 1994    
Most Recent Transcriptional regulatory elements of hif1α in a distal locus of islet1 in Xenopus laevis., Comp Biochem Physiol B Biochem Mol Biol 2021  
All View All Papers 40 paper(s) referencing morpholinos 8 paper(s) referencing OMIMs 11 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 27 terms 10 terms 13 terms
PANTHER nkx2-5
KEGG Pathways K09345 K09345 K09345
KOG [K] Transcription factor tinman/NKX2-3, contains HOX domain
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks nkx2-5
Transgenes Tg(nkx2.5:GFP) Tg(nkx2.5:GFP) Tg(nkx2.5:GFP)
Morpholinos nkx2-5 MO1 nkx2-5 MO1 , nkx2-5 MO1 nkx2-5 MO1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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