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Summary Expression Gene Literature (108) GO Terms (25) Nucleotides (247) Proteins (48) Interactants (363) Wiki
XB-GENEPAGE-999973
Gene Symbol:
mcm2

Gene Name:
minichromosome maintenance complex component 2

Synonyms:
XMcm2 , bm28 , ccnl1 , cdcl1 , cdc19 , mitotin ( Add synonyms , Nomenclature history )

Gene Function:
DNA replication licensing factor, MCM2 component

Protein Function :
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.



Interactants:
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Diseases: 


Disease Ontology:
autosomal dominant nonsyndromic deafness

OMIM:
DEAFNESS, AUTOSOMAL DOMINANT 70; DFNA70

External Links:
 
Xenbase Gene ID XB-GENE-999974 XB-GENE-999979 XB-GENE-17342436
Gene Symbol mcm2 mcm2.L mcm2.S
Chromosome Chr4 chr4L chr4S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 448458
380451
108715875
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine mcm2 mcm2.L mcm2.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards MCM2 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Mcm2 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Mcm2 Ensembl
zebrafish
ZFIN, AGR mcm2 ZFIN Ensembl
chicken
GEISHA MCM2 Ensembl
fruit fly
FLYBASE Mcm2 Ensembl
Publications
First Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication., Nucleic Acids Res 1992  
Most Recent Single-strand DNA breaks cause replisome disassembly., Mol Cell 2021    
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 25 terms 13 terms 11 terms
PANTHER mcm2
KEGG Pathways K02540 K02540 K02540
KOG [L] DNA replication licensing factor, MCM2 component
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks mcm2
Antibodies Mcm2 Ab1 , Mcm2 Ab2 , Mcm2 Ab3 Mcm2 Ab1 , Mcm2 Ab2 , Mcm2 Ab3 Mcm2 Ab3
ORFs mcm2.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

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