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Summary Expression Gene Literature (202) GO Terms (32) Nucleotides (389) Proteins (75) Interactants (193) Wiki
XB-GENEPAGE-494199
Gene Symbol:
grin1

Gene Name:
glutamate ionotropic receptor NMDA type subunit 1

Synonyms:
NR1 , nmda1 , nmdar1 ( Add synonyms , Nomenclature history )

Gene Function:
glutamate receptor channel component

Protein Function :
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requi...[+]


InterPro :
Peripla BP I , Glu/Gly-bd , Iontro rcpt , ANF lig-bd rcpt [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal dominant non-syndromic intellectual disability [+]

OMIM:
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, [+]

External Links:
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Xenbase Gene ID XB-GENE-494200 XB-GENE-866327 XB-GENE-17335935
Gene Symbol grin1 grin1.L grin1.S
Chromosome Chr8 chr8L chr8S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model
Entrez Gene 780048
397953
mRNA RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine grin1 grin1.L grin1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC AGR, OMIM:Gene, GeneCards GRIN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Grin1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Grin1 Ensembl
zebrafish
chicken
GEISHA GRIN1 Ensembl
fruit fly
worm
Publications
First Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs., Nature 1992  
Most Recent Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology., Nat Commun 2020                      
All View All Papers 1 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 28 terms 11 terms 0 term
PANTHER grin1
KEGG Pathways K05208 K05208
KOG [PET] NMDA selective glutamate-gated ion channel receptor subunit GRIN1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks grin1
Antibodies Grin1 Ab1 , Grin1 Ab2 Grin1 Ab1 , Grin1 Ab2 Grin1 Ab1 , Grin1 Ab2
Morpholinos (on-target & off-target) grin1 MO1 , grin1 MO2 grin1 MO1 , grin1 MO2
ORFs grin1 ORF1
Clones Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info