Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (172) GO Terms (21) Nucleotides (198) Proteins (47) Interactants (1812) Wiki
Gene Symbol:

Gene Name:
notochord homeobox

Xnot , noto , Xnot-2 , Xnot2 , flh , floating head , Znot , not-a , not-b , not1 , Xnot1 ( Add synonyms , Nomenclature history )

Gene Function:
homeodomain transcription factor

Protein Function :
Transcriptional repressor. Plays a fundamental role in notochord formation, acting within the mesodermal region. Acts downstream of gsc and upstream of chrd and foxa4-A/pintallavis.

Loading ...


External Links:
Xenbase Gene ID XB-GENE-478518 XB-GENE-6252631 XB-GENE-865187
Gene Symbol not not.L not.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100038059
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein RefSeq RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine not not.L not.S
Phenotype X. tropicalis X. laevis.L X. laevis.S
Smith Morpholino Screen tgas141c24      
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
Protein Atlas
ZFIN, AGR noto ZFIN Ensembl
fruit fly
FLYBASE not Ensembl
First The evolution of vertebrate gastrulation., Dev Suppl 1992  
Most Recent Furry is required for cell movements during gastrulation and functionally interacts with NDR1., Sci Rep 2021                                    
All View All Papers 40 paper(s) referencing morpholinos 3 paper(s) referencing OMIMs 7 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 18 terms 7 terms 7 terms
KEGG Pathways
KOG [K] Transcription factor EMX1 and related HOX domain proteins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks not
ORFs not.L ORF1 not.S ORF1
Clones EXRC Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info