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Summary Expression Gene Literature (34) GO Terms (55) Nucleotides (95) Proteins (42) Interactants (565) Wiki
XB-GENEPAGE-486780
Gene Symbol:
axin1

Gene Name:
axin 1

Synonyms:
xAxin , axin , fused ( Add synonyms , Nomenclature history )

Gene Function:
negative regulator of the wnt signaling pathway

Protein Function :
Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via tw...[+]


InterPro :
VDCC L a1su , VDCC L a1F , VDCC a1su IQ , GPHH dom [+]

Interactants:
Loading ...

Diseases: 


Disease Ontology:
hepatocellular carcinoma

OMIM:
HEPATOCELLULAR CARCINOMA [+]

External Links:
 
Xenbase Gene ID XB-GENE-486781 XB-GENE-17339457 XB-GENE-865645
Gene Symbol axin1 axin1.L axin1.S
Chromosome Chr9 chr9_10L chr9_10S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100498631
398097
734298
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine axin1 axin1.L axin1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards AXIN1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Axin1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Axin1 Ensembl
zebrafish
ZFIN, AGR axin1 ZFIN Ensembl
chicken
GEISHA AXIN1 Ensembl
fruit fly
Publications
First Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain., Mech Dev 1999      
Most Recent GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery., Cell Rep 2020                                        
All View All Papers 2 paper(s) referencing morpholinos 2 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 51 terms 13 terms 9 terms
PANTHER axin1
KEGG Pathways K02157 K02157 K02157
KOG [T] G protein signaling regulators
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks axin1
ORFs axin1.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info