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Summary Expression Gene Literature (4) GO Terms (15) Nucleotides (285) Proteins (42) Interactants (102) Wiki
XB-GENEPAGE-5840592
Gene Symbol:
hmgcr

Gene Name:
3-hydroxy-3-methylglutaryl-CoA reductase

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase

Protein Function :
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in ce...[+]



Interactants:
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Diseases: 


OMIM:
3-HYDROXY-3-METHYLGLUTARYL-CoA REDUCTASE; HMGCR

External Links:
 
Xenbase Gene ID XB-GENE-5840593 XB-GENE-5840728 XB-GENE-17334952
Gene Symbol hmgcr hmgcr.L hmgcr.S
Chromosome Chr1 chr1L chr1S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 100380121
397750
108707262
mRNA NCBI Nucleotide NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein NCBI Protein  More.. RefSeq Swiss-Prot  More.. NCBI Protein NCBI Protein  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine hmgcr hmgcr.L hmgcr.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, HMGCR Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Hmgcr MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Hmgcr Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR hmgcra hmgcrb ZFIN Ensembl
chicken
GEISHA HMGCR Ensembl
fruit fly
FLYBASE Hmgcr Ensembl
Publications
First Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions., Biochem Pharmacol 2007  
Most Recent Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Sci Rep 2020                        
All View All Papers
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 14 terms 9 terms 8 terms
PANTHER hmgcr
KEGG Pathways K00021 K00021
KOG [I] 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks hmgcr
ORFs hmgcr.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info