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Summary Expression Gene Literature (66) GO Terms (34) Nucleotides (220) Proteins (44) Interactants (402) Wiki
XB-GENEPAGE-6053329
Gene Symbol:
raf1

Gene Name:
Raf-1 proto-oncogene, serine/threonine kinase

Synonyms:
c-raf , raf-1 , craf ( Add synonyms , Nomenclature history )

Gene Function:


Protein Function :
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining ...[+]



Interactants:
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Diseases: 


Disease Ontology:
Noonan syndrome 5 [+]

OMIM:
LEOPARD SYNDROME 2; LPRD2 [+]

External Links:
1/2
 
Xenbase Gene ID XB-GENE-6053330 XB-GENE-17346605 XB-GENE-6053397
Gene Symbol raf1 raf1.L raf1.S
Chromosome Chr4 Scaffold24 Scaffold32
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 549871
108704012
397857
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine raf1 raf1.L raf1.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards RAF1 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Raf1 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Raf1 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR raf1b raf1a ZFIN Ensembl
chicken
GEISHA RAF1 Ensembl
fruit fly
Publications
First Nucleotide sequence of Xenopus C-raf coding region., Nucleic Acids Res 1988  
Most Recent Sprouty2 regulates positioning of retinal progenitors through suppressing the Ras/Raf/MAPK pathway., Sci Rep 2020                        
All View All Papers 2 paper(s) referencing morpholinos 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 34 terms 0 term 10 terms
PANTHER raf1
KEGG Pathways K04366 K04366
KOG
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks raf1
ORFs raf1 ORF1 raf1.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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