Gene Symbol : fbxo31 Gene Name : F-box protein 31 Synonyms: fbx14 , fbx31 , fbxo14 , fbxo31-b , fbxo31-a [-] ( Add synonyms , Nomenclature history ) Gene Function: Cdc4 and related F-box and WD-40 proteins Protein Function : Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubi...[+] Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. [-] InterPro : F-box dom , FBXO31 , F-box-like dom sf , Cortexin Interactants: Loading ... Diseases:  Disease Ontology: autosomal recessive non-syndromic intellectual disability OMIM: INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 45; MRT45 External Links: ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD

Expression	Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information	Xenbase Expression Details In situ images Single cell data at SPRING

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