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Summary Expression Gene Literature (10) GO Terms (29) Nucleotides (275) Proteins (45) Interactants (1091) Wiki
XB-GENEPAGE-974981
Gene Symbol:
cul3

Gene Name:
cullin 3

Synonyms:
cul3-a , cul3-b ( Add synonyms , Nomenclature history )

Gene Function:
E3 ubiquitin ligase component

Protein Function :
Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-prote...[+]


InterPro :
Cullin homology , Cullin homology sf , Cullin repeat-like dom sf , WH DNA-bd sf [+]

Interactants:
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Diseases: 


OMIM:
PSEUDOHYPOALDOSTERONISM, TYPE IIE; PHA2E

External Links:
 
Xenbase Gene ID XB-GENE-974982 XB-GENE-974989 XB-GENE-6256683
Gene Symbol cul3 cul3.L cul3.S
Chromosome Chr5 chr5L chr5S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 548729
446487
444103
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More.. RefSeq Swiss-Prot  More..
Genomic
 X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine cul3 cul3.L cul3.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards CUL3 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Cul3 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Cul3 Ensembl
zebrafish
ZFIN, AGR ZFIN, AGR cul3a cul3b ZFIN Ensembl
chicken
GEISHA CUL3 Ensembl
fruit fly
FLYBASE Cul3 Ensembl
Publications
First Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development., Dev Dyn 2008                
Most Recent Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis., J Clin Invest 2020  
All View All Papers 3 paper(s) referencing OMIMs 3 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 29 terms 26 terms 26 terms
PANTHER cul3
KEGG Pathways K03869 K03869 K03869
KOG [D] Cullins
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks cul3
Morpholinos cul3 MO1 hey1 MO2 , hey1 MO2 , cul3 MO1
ORFs cul3.L ORF1 cul3.S ORF1
Clones Horizon Source BioScience Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

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