Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Gene Literature (3) GO Terms (17) Nucleotides (125) Proteins (35) Interactants (47) Wiki
XB-GENEPAGE-995167
Gene Symbol:
clcn7

Gene Name:
chloride channel, voltage-sensitive 7

Synonyms:
( Add synonyms , Nomenclature history )

Gene Function:
Cl- channel CLC-7 and related proteins (CLC superfamily)

Protein Function :



Interactants:
Loading ...

Diseases: 


Disease Ontology:
autosomal dominant osteopetrosis 2 [+]

OMIM:
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 1; OPTB1 [+]

External Links:
 
Xenbase Gene ID XB-GENE-995168 XB-GENE-995173 XB-GENE-17339444
Gene Symbol clcn7 clcn7.L clcn7.S
Chromosome Chr9 chr9_10L
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1
CDS Gene model Gene model
Entrez Gene 733969
444161
mRNA RefSeq NCBI Nucleotide
Protein NCBI Protein RefSeq  More.. NCBI Protein RefSeq  More..
Genomic
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine clcn7 clcn7.L clcn7.S
Orthology
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
human
HGNC, AGR, Monarch, OMIM, GeneCards CLCN7 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
mouse
MGI, AGR Clcn7 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
rat
RGD, AGR Clcn7 Ensembl
zebrafish
ZFIN, AGR clcn7 ZFIN Ensembl
chicken
GEISHA CLCN7 Ensembl
fruit fly
Publications
First Common gating of both CLC transporter subunits underlies voltage-dependent activation of the 2Cl-/1H+ exchanger ClC-7/Ostm1., J Biol Chem 2013  
Most Recent Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification., Am J Hum Genet 2019  
All View All Papers 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 17 terms 2 terms 0 term
PANTHER clcn7
KEGG Pathways K05016 K05016
KOG [P] Cl- channel CLC-7 and related proteins (CLC superfamily)
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks clcn7
ORFs clcn7.L ORF1
Clones Horizon Source BioScience Horizon Source BioScience
Plasmids Addgene Addgene

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info