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Summary Expression Gene Literature (28) GO Terms (21) Nucleotides (236) Proteins (52) Interactants (374) Wiki
Gene Symbol:

Gene Name:
NDC80 kinetochore complex component

xndc80 , hec1 , kntc2 ( Add synonyms , Nomenclature history )

Gene Function:
Centromere-associated protein HEC1

Protein Function :
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12514103, PubMed:14738735). Required for ...[+]

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External Links:
Xenbase Gene ID XB-GENE-997352 XB-GENE-17345905 XB-GENE-997357
Gene Symbol ndc80 ndc80.L ndc80.S
Chromosome Chr2 chr2L chr2S
Molecules X. tropicalis X. laevis.L X. laevis.S
Genomic Sequence Version 10.0 Version 9.1 Version 9.1
CDS Gene model Gene model Gene model
Entrez Gene 496580
mRNA RefSeq NCBI Nucleotide NCBI Nucleotide
Protein RefSeq Swiss-Prot  More.. NCBI Protein RefSeq  More.. RefSeq Swiss-Prot  More..
X. tropicalis X. laevis.L X. laevis.S
Genome Browser
(Click image to open in Genome Browser)
Genomic Synteny Genomicus PANTHER
Expression                  Development Stages    Embryonic TissuesAdult Tissues
Summary for
More Information
Xenbase Expression Details In situ images Single cell data at SPRING Ensembl In situ: Single cell: RNA-Seq:
Proteomics X. tropicalis X. laevis.L X. laevis.S
Embryonic Protein Expression Stage profile: Stage profile:
Data Mining X. tropicalis X. laevis.L X. laevis.S
XenMine ndc80 ndc80.L ndc80.S
Knowledgebases Entrez Gene Genetic Phenotypes Gene Expression
HGNC, AGR, Monarch, OMIM, GeneCards NDC80 OMIM Ensembl, Allen Brain Atlas, Protein Atlas
MGI, AGR Ndc80 MGI, IMPC Ensembl, Allen Brain Atlas, Eurexpress, MGI
RGD, AGR Ndc80 Ensembl
ZFIN, AGR ndc80 ZFIN Ensembl
GEISHA NDC80 Ensembl
fruit fly
FLYBASE Ndc80 Ensembl
First The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity., Genes Dev 2003  
Most Recent Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome., Life Sci Alliance 2019                                    
All View All Papers 1 paper(s) referencing morpholinos 1 paper(s) referencing OMIMs 1 paper(s) referencing Disease Ontology
Functional Ontologies X. tropicalis X. laevis.L X. laevis.S
GO 21 terms 6 terms 11 terms
KEGG Pathways K11547 K11547 K11547
KOG [D] Centromere-associated protein HEC1
Reagents X. tropicalis X. laevis.L X. laevis.S
CRISPRscan Tracks ndc80
ORFs ndc80 ORF1 kntc2 ORF1 ndc80.S ORF1
Clones Horizon Source BioScience Horizon Horizon Source BioScience
Plasmids Addgene Addgene

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