XB-GENEPAGE-
481981
Protein sequences for zic1 - All
Models (26)
| Source | Version | Model | Species |
| NCBI | 10.1 |
XBmRNA48581
 |
X. laevis.S |
| NCBI | 10.1 |
XBmRNA45132
|
X. laevis.L |
| NCBI | 10.0 |
mRNA036817
|
X. tropicalis |
| Xenbase | 9.2 |
rna48410
|
X. laevis.L |
| Xenbase | 9.2 |
rna76446
|
X. laevis.S |
| JGI | 9.1 |
Xelaev18027743m
|
X. laevis.L |
| JGI | 9.1 |
Xelaev18029829m
|
X. laevis.S |
| JGI | 8.0 |
Xetrov14021742m
|
X. tropicalis |
| JGI | 7.1 |
Xetro.E00027.1
|
X. tropicalis |
| JGI | 7.1 |
Xetro.E00027.2
|
X. tropicalis |
| JGI | 6.0 |
XeXenL6RMv10002521m
|
X. laevis.S |
| JGI | 4.1 |
fgenesh1_pm.C_scaffold_284000008
|
X. tropicalis |
| JGI | 4.1 |
gw1.284.59.1
|
X. tropicalis |
| JGI | 4.1 |
e_gw1.284.59.1
|
X. tropicalis |
| JGI | 4.1 |
gw1.284.80.1
|
X. tropicalis |
| JGI | 4.1 |
gw1.284.60.1
|
X. tropicalis |
| JGI | 4.1 |
e_gw1.284.60.1
|
X. tropicalis |
| JGI | 4.1 |
e_gw1.284.80.1
|
X. tropicalis |
| ENSEMBL | 4.1 |
ENSXETP00000033767
|
X. tropicalis |
| JGI | 4.1 |
estExt_fgenesh1_pg.C_2840027
|
X. tropicalis |
| JGI | 4.1 |
estExt_fgenesh1_pm.C_2840008
|
X. tropicalis |
| JGI | 4.1 |
estExt_FilteredModels1.C_2840015
|
X. tropicalis |
| JGI | 4.1 |
estExt_Genewise1.C_2840059
|
X. tropicalis |
| JGI | 4.1 |
estExt_Genewise1.C_2840060
|
X. tropicalis |
| JGI | 4.1 |
estExt_Genewise1.C_2840080
|
X. tropicalis |
| JGI | 4.1 |
fgenesh1_pg.C_scaffold_284000027
|
X. tropicalis |
|
UniProtKB Protein Function:
Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border. Cooperates with pax3 in concert with wnt signaling to determine neural crest fate. Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
|
AI Protein Function  :
zic1 is a zinc‑finger transcription factor of the GLI‑type C2H2 class that localizes to the nucleus and acts as a transcriptional repressor. It is expressed in the neural plate, neural plate border, dorsal neural tube, forebrain, midbrain, hindbrain, eye primordia and cranial neural crest, where it regulates neural plate border specification, maintenance of neural progenitor identity, dorsal forebrain patterning and eye field formation. Loss of zic1 function leads to reduced expression of neural markers and defects in neural tube closure and eye development. Overexpression expands neural plate border domains and promotes ectopic neurogenic differentiation.
|
NCBI Proteins (13)
| Accession | Species | Source |
| KAE8604290
|
X. tropicalis | RefSeq |
| KAE8604291
|
X. tropicalis | RefSeq |
| NP_001432287
|
X. tropicalis | RefSeq |
| XP_002937379
|
X. tropicalis | NCBI Protein |
| AAB99946
|
X. laevis.S | NCBI Protein |
| AAC14214
|
X. laevis.S | NCBI Protein |
| BAA33406
|
X. laevis.S | NCBI Protein |
| NP_001083799
|
X. laevis.S | RefSeq |
| OCT78740
|
X. laevis.S | NCBI Protein |
| OCT80931
|
X. laevis.L | NCBI Protein |
| XP_018119320
|
X. laevis.L | NCBI Protein |
UniProt Proteins (2)
| Accession | Species | Source |
| O73689
(InterPro)
|
X. laevis.S | Swiss-Prot |
| A0A1L8GAZ5
(InterPro)
|
X. laevis.L | TrEMBL |