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cdkn1axenopus   

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Experiment details for cdkn1a

Zhang Z et al. (2017) Assay

Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.

Gene Clone Species Stages Anatomy
cdkn1a.L laevis NF stage 15 to NF stage 20 ectoderm , cement gland primordium
cdkn1a.L laevis NF stage 26 to NF stage 32 otic vesicle , cement gland , somite , eye , lens placode

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  FIGUTRE 8. Genes repressing or being downregulated during cancer development/progression show varied expression patterns in Xenopus embryos. A, spatial expression patterns were examined with WMISH. Embryos at the same stages as shown in Fig. 6 were used and presented in the same way as in Fig. 6. A, anterior; ad, adenohypophysial placode; ba, branchial arch; cg, cement gland; cgp, cement gland primordium; ep, epidermis; ev, ear vesicle; ey, eye; fb, forebrain; hb, hindbrain; le, lens; mb, midbrain; mhb, midbrain-hindbrain boundary; nc, notochord; nu, neuron; np, neural plate; nt, neural tube; P, posterior; pn, pronephros; pm, paraxial mesoderm; ps, posterior somite; sm, somite; tg, trigeminal nerve. B, summary of the relatedness of gene expression/function in cancer and their expression.