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Gene/CloneSpeciesStageAnatomy ItemExperimenter
chrd.1xenopus vegetal part, early involuting 

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Experiment details for chrd.1

Kenwrick S et al. (2004) Assay

Pilot morpholino screen in Xenopus tropicalis identifies a novel gene involved in head development.

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Gene Clone Species Stages Anatomy
chrd.1 tropicalis NF stage 10.25 vegetal part, early involuting

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  Figure 2. A: Reproducible phenotypes induced by morpholino (MO) injection. Control uninjected embryos and embryos injected with each MO, as indicated. All are hybridised with a neural marker (blue staining), apart from (p–s) which are unstained, as follows: a–d, ElrC; e,f, Sox3; g–o, N-tubulin. The main features of the phenotypes caused by the MOs were as follows: 16G8 causes shortening of the anterior–posterior axis, 26A10.2 causes a reduction of ElrC staining particularly in the cranial nerve region (arrowhead in d) and broadening of the hindbrain (arrowhead in f), 17D4 causes posterior truncation (h) and/or bifurcated axis (i), 26E1.1 results in enhanced posterior development/open proctodeum (arrowhead in k and l) and hypodorsalisation, 18E6 causes cell death that starts anteriorly (n) and spreads posteriorly (o), and 25H12.1 causes extreme microcephaly. Most are lateral views apart from e,f,m,n,o,r,s, which are dorsal views. Anterior is to the left in all panels. Each set of control and experimental embryos was photographed under the same magnification (×40–×60). B: Expression patterns of targeted genes by in situ hybridisation. a: Expression of 16G8 (blue) along the neural tube of a neurula embryo. b: Expression of 16G8 (magenta) in a broad band around the equator of a gastrulating embryo, blastopore side down. c: 26A10.2 expression is high in neural tissue of neurula embryos. d: 17D4 expression in a neurula embryo. e: 26E1.1 expressed at the anterior neural tube. f: 18E6 expression at the anterior end of the neural tube. g: 25H12.1 expression in mid-anterior neural plate in two bilateral patches (black arrowhead) and the anterior neural ridge (white arrowhead). h,i: 25H12.1 is expressed around the blastopore of gastrulating embryos but excludes the dorsal mesoderm highlighted by in situ hybridisation to chordin (in light blue). All neurula embryos are viewed from the dorsal side with anterior to the front.