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Fig. 1. Distribution of Xevl transcripts in the Xenopus inner ear. (A) Diagram of the otic region. (B-E) In situ hybridizations on transverse sections through the otic region. The neural tube is at the top of the panels, the otic vesicle is located ventrolateral to the neural tube, and the vestibulocochlear ganglion resides between the otic vesicle and the neural tube. Nieuwkoop and Faber stages are indicated in the upper right corners. (B) Xevl is enriched in the ventromedial region of the otic vesicle at stage 25. (C) At stage 30, Xevl continues to be enriched in the ventromedial region of the otic vesicle as well as in cells delaminating from this region (arrow). (D) At stage 35, Xevl expression is found in the ventromedial region of the otic vesicle that will give rise to the sensory epithelium of the saccular maculae (arrowhead) as well as in the vestibulocochlear ganglion (arrow). (E) At stage 45, Xevl is enriched at the presumptive sensory epithelium (arrowhead) and is weakly expressed in the vestibulocochlear ganglion (arrow). ov, otic vesicle; vg, vestibulocochlear ganglion. Bar, 100 µm. |
