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fgf8xenopus   

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Experiment details for fgf8

FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus.

FGF-8 is associated with anteroposterior patterning and limb regeneration in Xenopus.

Gene Clone Species Stages Anatomy
fgf8.L laevis NF stage 10 marginal zone
fgf8.L laevis NF stage 11 marginal zone
fgf8.L laevis NF stage 14 ectoderm , midbrain-hindbrain boundary , hatching gland , circumblastoporal collar , anterior , [+]
fgf8.L laevis NF stage 20 forebrain , midbrain-hindbrain boundary , hatching gland , mesoderm , axial mesoderm , [+]
fgf8.L laevis NF stage 33 and 34 otic vesicle , forebrain , midbrain-hindbrain boundary , mandibular crest , hyoid crest , [+]

  FIG. 3. Spatial expression of XFGF-8 during early development. Detection by whole-mount in situ hybridization of XFGF-8 DIG-labeled antisense RNA. (A) Vegetal view of a stage 10 embryo. XFGF-8 expression comes up in a ring around the future blastopore. (B) Vegetal view of a stage 11 embryo. Expression around blastopore broadens. (C and D) Dorsal and anterior view, respectively, of a stage 14 embryo. XFGF-8 transcribed in two patches in the future midbrain/hindbrain junction (black arrowheads), the prospective hatching gland region (white arrow), and an epidermal crescent outside the neural plate area (black arrow). Periblastoporal expression becomes localized to the posterior. (E) Side view of stage 20 embryo. Transcription in future hatching gland is increased and the expression previously seen in a crescent outside the neural plate territory has now moved to a lateral epidermal fold. (F, G, and I) Stage 33 embryos. (F and G) While expression in the hatching gland and frontal plate (white arrow) and the midbrain/hindbrain junction (black arrowhead) persists, new expression domains are detected in the forebrain (fb), the ear vesicle (e), the notochord, and the pronephros (*). The lateral epidermal fold expression is now seen in the branchial clefts (bc). In the tail, transcripts are confined to the tail bud (tb). (H) Close-up of stage 38 tail bud. (I) Sections of whole-mount in situs. (I and K) Parasagittal sections through the head showing the expression at the midbrain/ hindbrain junction (black arrowhead) and labeling in the forebrain adjacent to the frontal plate (fb). (L) Parasagittal section through the tail bud. Transcripts are detected in the posterior wall (pw) of the neuroenteric canal and the chordoneural hinge (cnh).