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Figure 7. An early Fgf signal is important for development of the ventronasal periocular mesenchyme (POM). A–D, I, J: foxc1 expression in the POM around the eye at Stage 32 in embryos treated with control or Fgfr inhibitor solutions at Stage 12 (A–D) and Stage 24 (I, J). E–H: fgfr2 expression in the POM of Stage-32 embryos treated with a control or SU5402 solution at Stage 12. White dashed lines indicate the gap in expression as seen in the lateral view of wholemount embryos after in situ hybridization for foxc1 or fgfr2 expression in the POM of Stage-32 embryos treated with a control. Images in B, D, F, and H are of vibratome transverse sections through the eyes (outlined with black dots) of wholemount embryos, and the white arrows indicate the ventral POM, where expression is diminished after SU5402 treatment. Grey dashed lines iindicate the outline of the developing neural retina.Download figure to PowerPoint |
