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foxg1xenopus   

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Experiment details for foxg1

Galli A et al. (2003) Assay

Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos.

Gene Clone Species Stages Anatomy
foxg1.L laevis NF stage 14 telencephalon

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  Fig. 1. Gpc4 expression during early development of Xenopus embryos. Arrowheads (B-F) point to the dorsal blastopore lip. (A) Blastula (stage 7) showing localization of Gpc4 transcripts in the animal hemisphere. AP, animal pole; VP, vegetal pole. (B) Expression of Gpc4 at the onset of gastrulation (stage 10). (C) Dorso-vegetal view of an early gastrula stage embryo (stage 10.5). The broken line indicates the plane of the hemi-sections shown in panels D-F and I. (D-F) Hemi-sections of embryos cut along the dorsoventral axis (stage 10.5). (D) Gpc4 transcripts in prechordal endomesoderm and chordamesoderm (asterisk) and in the neuroectodermal cell layer (arrow). (E) Distribution of Noggin transcripts in the prechordal endomesoderm and chordamesoderm (asterisk). (F) Sox2 in the neuroectodermal cell layer (arrow). (G) Frontal view of an early neural plate embryo (stage 14). Note Gpc4 transcripts in the anterior neural plate (black arrow) and presumptive spinal cord (white arrow). (H) Frontal view of a stage 14 embryo showing Bf1 expression in the anterior forebrain. (I) Expression of Gpc4 in a hemi-sectioned embryo (stage 14). Anterior is to the left. The white arrowhead points to decreasing expression in the prechordal plate. (J) Frontal view of a mid-neurula (stage 17). Asterisks point to Gpc4 transcripts in the presumptive dorsal forebrain. (K) Emx2 expression in the presumptive dorsal forebrain (stage 17; asterisks). (L) Expression of Gpc4 following closure of the anterior neural tube (stage 20). Arrow points to transcripts in the forebrain.

Gene Clone Species Stages Anatomy
foxg1.L laevis NF stage 21 telencephalon , olfactory region

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  Fig. 5. GPC4 regulates expression of dorsal forebrain markers. Molecular analysis of neural markers in CoMo- and Gpc4Mo-injected embryos. (A-D,G-N) Frontal views; (E,F) dorsal views; (O-R) side view. Anterior is to the left. (A,B) Otx2 expression (stage 21). Arrowhead indicates forebrain expression; asterisk indicates midbrain expression. (C,D) Bf1 expression (stage 21). Arrows indicate expression in the developing telencephalon; arrowhead indicates expression in the olfactory placodes. (E,F) Expression of the posterior neural markers Krox20 (bracket) and Hoxb9 (arrowhead) in stage 21 embryos. (G,H) Fgf8 expression (stage 17). Asterisk indicates anterior neural ridge; arrowhead indicates isthmus. (I,J) Nkx2.1 expression in the ventral forebrain (stage 21); note that Nkx2.1 expression persists in GPC4-depleted embryos (J). (K,L) Emx2 expression in the dorsal forebrain of developing embryos (stage 21); note that Emx2 expression is drastically reduced in GPC4-depleted embryos (L). (M) Emx2 expression in embryos co-injected with CoMo and mouse Gpc4 (mGpc4) mRNA; note that overexpression of mouse Gpc4 does not affect Emx2 expression (compare with K). (N) Rescue of Emx2 expression in embryos co-injected with Gpc4Mo and mouse Gpc4 mRNA (compare with L). (O) Emx2 expression in a tailbud embryo injected with CoMo. (P) Emx2 expression in a tailbud embryo co-injected with CoMo and mouse Gpc4 mRNA. (Q) Loss of Emx2 expression in a tailbud embryo injected with Gpc4Mo. (R) Rescue of Emx2 expression and forehead morphology in a tailbud embryo co-injected with Gpc4Mo and mouse Gpc4 mRNA.