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fzd4xenopus   

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Experiment details for fzd4

Fish MB et al. (2015) Assay

Xenopus mutant reveals necessity of rax for specifying the eye field which otherwise forms tissue with telencephalic and diencephalic character.

Gene Clone Species Stages Anatomy
fzd4 tropicalis NF stage 15 pre-chordal neural plate , eye primordium , optic vesicle , neural tube

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  Fig. 7. Genes with altered expression in rax mutants include those necessary for retina formation and forebrain patterning. (A) Table listing key up-regulated (red) and down-regulated (blue) genes from RNA-Seq analysis. (All significantly affected genes identified in this analysis can be found in Table S4) (B) In situ hybridization for up-regulated genes in St. 15 embryos. White arrows indicate regions where up-regulation is observed in mutants in the presumptive retinal field. (C) In situ hybridization for down-regulated genes in St. 15 embryos. White arrows indicate regions in the eye field where expression is not detected in the mutant. (D) vsx1 expression (arrows) at neural plate stage is reduced in the heterozygote compared to wildtype and not detected in rax homozygous mutant embryos. (E) A time course of fezf2 and hesx1 expression from late gastrula (St. 12) through neural tube stage (St. 21) in rax mutant and wildtype embryos. White arrows indicate regions where repression is seen in wildtype embryos and not observed in rax mutants.