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Fig. 2. Fgf is required for the patterning of late LPM markers. Hand1 (A and B) and foxf1 (C and D) are normally restricted in the anterior and middle LPM with a clear domain free of expression in both cases. When embryos are treated with SU5402, both hand1 (B) and foxf1 (D) are expressed along the entire anterior–posterior axis. Conversely, the LPM expression domains of both hoxc10 (E and F; normally expressed in the posterior half of the LPM) and tnni3 (G and H; marker of cardiac differentiation) are completely undetectable when Fgf signalling is inhibited. (A–F): lateral view of the embryos is shown, with anterior toward the left, dorsal at top. (G–H); ventral view of the heart region is shown, with anterior toward left. The total number of embryos examined for each panel is indicated in the lower left hand corner.
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