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Gene/CloneSpeciesStageAnatomy ItemExperimenter
kcnd3xenopus midbrain [+] 

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Experiment details for kcnd3

McFarlane S and Pollock NS (2000) Assay



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Gene Clone Species Stages Anatomy
kcnd3.L laevis NF stage 33 and 34 to NF stage 37 and 38 midbrain

  Fig. 2. Developing RGCs express Kv channels. A, B, Kv currents recorded from two different stage 33/34 equivalent RGCs in culture in the whole-cell configuration (see Materials and Methods). The cells were held at holding potential of −80 mV, and 400 msec voltage steps were applied in 10 mV increments from −60 to +70 mV. In both cells, outward Kv currents are observed that are sensitive to both 3 mM 4-AP and 50 mMTEA. With the cell shown in B, wash out with control solution was able to reverse the blockade. C–E,Immunolabeling with a rabbit polyclonal antibody against rat Kv4.3.C, D, Transverse sections through stage 33/34 (C) and stage 37/38 (D) retinas showing labeling of cells in the RGC layer. PE, Pigment epithelium; L, lens; onh, optic nerve head; mb, midbrain; RGCL, RGC layer; D, dorsal; V, ventral.E, An RGC growth cone in culture immunolabeled with the Kv4.3 antibody. The body of the growth cone, the filopodia, and the lamellopodia are labeled in a punctate fashion. Scale bar (shown inE): C, 50 μm; D, 25 μm; E, 5 μm.