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Figure 2.
Inhibitors of H+/K+-ATPase Activity Perturb Sidedness of Asymmetric Gene Expression in Xenopus
Examples of ectopic right-sided and absent expression of genes normally expressed in the left lateral mesoderm as detected by in situ hybridization.
Left (A–F) and right (A′–F′) flanks of embryos probed for XNr-1 (A-C′, stages 22–24), Pitx-2 (D–F′, stages 28–30) expression.
(G and H) Transverse histological sections of stages 28–30 embryos showing left-sided lefty expression in an untreated embryo (G) and bilateral expression in a treated embryo (H). In all images, arrowheads indicate normal (red), absent (white) or ectopic (blue) expression.
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