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Fig. 2. pcdh8 / protocadherin 8 / PAPC is expressed during mesodermal mantle
morphogenesis. (A) PAPC expression in the dorsal marginal zone at
late blastula (stage 9G). (B) Expression expands around the marginal
zone at early gastrula (stage 10G). (C) Repression of PAPC
expression in the axial mesoderm prefiguring the segregation
between axial and paraxial mesoderm (stage 11G). (D) A sharp
anterior border separates head and trunk mesoderm (stage 13). (E) At
early neurula (stage 14), stripes of PAPC expression prefigure the
future somites. (F) As the first mature somite is segmented (stage
17), the anterior stripe disappears and new posterior stripes appear.
PAPC expression is also found in lateral plate mesoderm and in the
forming otic vesicle (not shown). (G) Transverse section of stage 13
embryo stained for PAPC in blue and chordin in brown by double in
situ hybridization; note PAPC expression exclusively in paraxial
mesoderm. (H) PAPC stripes during somite segmentation; the most
anterior PAPC stripe is in the mature somite (s), the second stripe
marks the forming somite (fs) and the more intense two posterior
stripes are located in the segmental plate (sp). (I) Transverse section
of stage 18 embryo showing AXPC expression exclusively in the
notochord. (J) Dorsal view of AXPC expression in the notochord
(stage 14), anterior to the left. (K) Lateral view of AXPC expression
in the notochord (stage 22). At later tailbud stages AXPC was
transiently expressed in developing heart and pronephros (data not
shown). Image from Kim et al., 1998. |
