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sox3xenopus   

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Experiment details for sox3

Griffin JN et al. (2015) Assay

The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus.

Gene Clone Species Stages Anatomy
sox3 tropicalis NF stage 14 pre-chordal neural plate , chordal neural plate , neural plate

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  Fig 3. Knockdown of nol11 disrupts cranial neural crest development. At stages 14 and 24 neural and CNC development appears normal in one side treated embryos, as assayed by expression of key marker genes including sox3, cytokeratin, twist and slug. By stage 28 however, reductions are apparent in the expression of numerous CNC genes. The branchial arches are also smaller on the MO treated side at stage 28. Graph displays number of embryos exhibiting abnormal gene expression in control and nol11 morphant embryos. doi:10.1371/journal.pgen.1005018.g003

Gene Clone Species Stages Anatomy
sox3 tropicalis NF stage 28 brain , forebrain , midbrain , hindbrain , spinal cord , [+]

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  S3 Fig. Patterning and Apoptosis in nol11 morphants. A) Somite, CNC and neural development appear intact in nol11 morphants at stage 14 as assayed by myoD, ap2 and pax2 expression. Expression of xnot appears reduced at stage 28. B) Reduced dlx5 expression and BA hypoplasia on treated side of a stage 28 embryo. Neural patterning is normal at this stage as assayed by expression of pax2, hoxb3 and sox3. C) Whole mount TUNEL staining of treated and untreated sides of a stage 28 embryo. Note the increased staining in the craniofacial regions of the morphant side. doi:10.1371/journal.pgen.1005018.s003