|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf8
|
|
laevis
|
NF stage 13
|
neuroectoderm
,
mesoderm
,
anterior
,
cardiac progenitor cell
|
isl1
|
|
laevis
|
NF stage 13
|
mesoderm
,
ventral
,
anterior
,
cardiac progenitor cell
|
gata6
|
|
laevis
|
NF stage 13
|
mesoderm
,
anterior
,
cardiac progenitor cell
|
nkx2-5
|
|
laevis
|
NF stage 13
|
mesoderm
,
ventral
,
anterior
,
cardiac progenitor cell
|
|
|
Fig. 1. Whole mount in situ hybridization of Xenopus laevis embryos at stage 13. The expression of Isl1, Nkx2.5, GATA6b, Tbx1, and FGF8b is given. Anterior views (upper row) of embryos are shown. Dashed lines indicate the level of sagittal sections shown in the lower row. e, endoderm; ect, ectoderm; m, mesoderm. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf8
|
|
laevis
|
NF stage 15
to
NF stage 29 and 30
|
midbrain-hindbrain boundary
,
neuroectoderm
,
mesoderm
,
pharyngeal arch
,
mandibular arch
,
[+]
|
isl1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
isl1
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart
,
heart primordium
,
anterior
|
dkk1
|
|
laevis
|
NF stage 15
to
NF stage 20
|
eye primordium
,
cranial placode
,
anterior neural tube
,
cardiac progenitor cell
|
dkk1
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
forebrain
,
heart
,
cardiac mesoderm
,
heart primordium
|
bmp2
|
|
laevis
|
NF stage 15
to
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
bmp4
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural groove
,
neural plate
,
lateral plate mesoderm
,
cardiac progenitor cell
|
gata5
|
|
laevis
|
NF stage 15
to
NF stage 20
|
mesoderm
,
cardiac progenitor cell
|
gata5
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
cardiac mesoderm
,
ventral
,
heart primordium
|
gata6
|
|
laevis
|
NF stage 15
to
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
gata6
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
alimentary system
,
intestine
,
liver and biliary system
,
cardiac mesoderm
,
heart primordium
,
[+]
|
tbx5
|
|
laevis
|
NF stage 15
to
NF stage 20
|
neural plate
,
lateral plate mesoderm
,
cardiac progenitor cell
|
tbx5
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart
,
cardiac mesoderm
,
heart primordium
|
tbx20
|
|
laevis
|
NF stage 15
|
cardiac progenitor cell
|
tbx20
|
|
laevis
|
NF stage 20
|
cement gland primordium
,
cardiac progenitor cell
|
tbx20
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart primordium
,
cardiac progenitor cell
|
gata4
|
|
laevis
|
NF stage 15
to
NF stage 20
|
cardiac progenitor cell
|
gata4
|
|
laevis
|
NF stage 20
to
NF stage 29 and 30
|
cardiac mesoderm
,
lateral plate mesoderm
,
heart primordium
,
cardiac progenitor cell
|
nkx2-5
|
|
laevis
|
NF stage 15
to
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
nkx2-5
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart
,
heart primordium
,
posterior
|
kdr
|
|
laevis
|
NF stage 15
to
NF stage 20
|
cardiac progenitor cell
|
kdr
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart primordium
,
vascular endothelium
,
cardiac progenitor cell
|
aplnr
|
|
laevis
|
NF stage 15
to
NF stage 20
|
lateral plate mesoderm
,
cardiac progenitor cell
|
aplnr
|
|
laevis
|
NF stage 24
to
NF stage 29 and 30
|
heart primordium
,
vascular endothelium
,
cardiac progenitor cell
|
|
|
Fig. 2. (A) Cardiac expression of Isl1, Nkx2.5, GATA4, GATA5, GATA6b, Xmsr and Flk1 in Xenopus embryos at stages 15/16, 20, 24 and 29 as indicated. (B) Cardiac expression of Tbx20, Tbx1, Tbx5, BMP2, BMP4, Dkk1, and FGF8b at different developmental stages of Xenopus laevis as indicated. For embryos at stages 15/16 and 20 anterior views are presented, whereas embryos at stage 24 and 29 are shown from the ventral side, anterior is to the top. Dotted lines indicate the cement gland. |
|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
fgf8
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
isl1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
dkk1
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
bmp2
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
bmp4
|
|
xenopus
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
gata5
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
endocardium
|
gata6
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
liver diverticulum
|
tbx5
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
tbx20
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
endocardium
|
gata4
|
|
xenopus
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
,
liver diverticulum
|
nkx2-5
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
myocardium
|
kdr
|
|
laevis
|
NF stage 29 and 30
to
NF stage 31
|
heart
,
endocardium
,
endocardial tube
|
aplnr
|
|
xenopus
|
NF stage 29 and 30
to
NF stage 31
|
heart
|
|
|
Fig. 6. (A) Serial transverse sections indicate the expression of Isl1, Nkx2.5, GATA4, GATA5, GATA6b, Xmsr and Flk1 in Xenopus laevis embryos at stage 30/31. (B) Spatial expression of Tbx20, Tbx1, Tbx5, BMP2, BMP4, Dkk1 and FGF8b at stage 30/31. The upper row provides a lateral view. Dashed lines depict the level of sections A, B and C as indicated. Level A corresponds to the anterior region of the heart. Level B is at the level of the closing heart tube. Level C is at the posterior end of the heart where the IFT forms later in development. |