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tp53xenopus nucleus 

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Experiment details for tp53

Differential subcellular sequestration of proapoptotic and antiapoptotic proteins and colocalization of Bcl-x(L) with the ge...



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Gene Clone Species Stages Anatomy
tp53.L laevis oocyte stage IV nucleus

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  FIG. 1. Proapoptotic proteins Bax and p53 are sequestered in Xenopus oocyte nucleus and excluded from the mitochondrial cloud. (A, B, D, F, G) Whole-mount and (C, E, H) section immunostaining of Stage I–II (A, F) albino, and (B, C and G, H) and Stage IV (D, E) wild type oocytes with Bax antibody. In (A–C) control and (F–H) heat-shocked Stage I–II oocytes, Bax protein is concentrated in the nucleus and excluded from the mitochondrial cloud (arrows in B, C, H). Arrow in F points to the heavily damaged oocyte with cytoplasmic blebbing. In Stage IV oocytes Bax is exluded from the nucleus and concentrated (arrow) in perinuclear region (D, E). Whole-mount (I) control and (J) heat-shocked oocytes immunostained with p53 antibody showing the protein concentrated in the nucleus and excluded from the mitochondrial cloud (arrows). The level of p53 expression seems to be similar in control and heat-shocked oocytes, the oocyte in panel J showing lower than control expression of p53 was chosen just to clearly visualize the mitochondrial cloud. N, nucleus. Scale bars represent 50 lm in A–C and F–J, 200 lm in D and 75 lm in E.