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Gene/Clone	Species	Stage	Anatomy Item	Experimenter
eya1	xenopus		non-neurogenic ectodermal placode

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Experiment details for eya1

Schlosser G and Ahrens K (2004) Assay

Molecular anatomy of placode development in Xenopus laevis.

Gene	Clone	Species	Stages	Anatomy
eya1.L		laevis	NF stage 13 to NF stage 14	lens placode

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Fig. 1. Placodal gene expression patterns in neural plate stage Xenopus embryos (stages 13–14) in dorsal view (anterior is to the left, all embryos are equally oriented). To facilitate comparison of the placodal expression domains of different genes, color-coded arrows and arrowheads corresponding to different placodal expression domains of Pax genes are used for the identification of comparable regions of gene expression (for more detailed labeling, see Fig. 12). Colors are explained in the schematic drawing, which depicts the approximate relative position of some gene expression domains and lists the placodes to which they will give rise subsequently. Green arrowheads identify placodal gene expression immediately rostral to the anterior neural plate border (prospective adenohypophysial placode medially and prospective olfactory placodes laterally), whereas green arrows identify placodal gene expression rostrolateral to the anterior neural plate (prospective lens and trigeminal placodes). Black arrows in D indicate the border of Dlx3 expression in superficial ectoderm, which extends further medial than its border of expression in the deep ectodermal layer (colored arrows). Black arrowheads in E indicate Msx1 expression in anterior neural plate. White asterisks in E and L indicate expression of Msx1 and Pax3, respectively, in a region encompassing neural crest and lateralmost neural plate. For detailed description, see text. Abbreviations: Ad/Ol, anterior placodal area, from which adenohypophysial (Ad) and olfactory (Ol) placodes develop; anp, anterior neural plate; cg, cement gland; L, lens placode; LL/Ot/EB, posterior placodal area, from which lateral line (LL), otic (Ot), and epibranchial (EB) placodes develop; np, neural plate; PN, pronephros; Pr, profundal placode; pnp, posterior neural plate; V, trigeminal placode.

Gene	Clone	Species	Stages	Anatomy
eya1.L		laevis	NF stage 18	adenohypophyseal placode

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Fig. 8. Changes in placodal gene expression patterns during neurulation in Xenopus embryos (stages 16–18). As in Fig. 1, color-coded arrows and arrowheads are used for the identification of comparable regions of gene expression indicated in the schematic drawing. Green arrowhead indicates the prospective olfactory placode. The green asterisk indicates an anterior subregion of the lateral Pax6-expressing domain, where panplacodal genes such as Eya1 and Six1 are downregulated during neurulation (note indentation in the red domain) and which will likely give rise to the lens placode. Green arrow indicates the posterior subregion of the lateral Pax6-expressing domain (prospective trigeminal placode). (A and B) Sagittal sections through the anterior neural folds reveal expression of Six1 (A) and Sox3 (B) in the deep ectodermal layer of the outer neural folds (black arrows). The outer ectodermal layer is indicated by black asterisks. (C–E) Frontal views of gene expression domains in neural fold stage Xenopus embryos. Note the separation of the anterior domain of Eya1 and Six1 expression (arrowheads) from the lateral domain (arrows) due to the elevation of the neural folds. (F–H) Lateral views of gene expression domains in neural fold stage Xenopus embryos. Note the downregulation of Eya1 (F), Six1 (G), and Msx1 (H) in a region that will likely give rise to the lens placode (green asterisk). The white asterisk in H indicates expression of Msx1 in a region encompassing neural crest and lateralmost neural plate. For detailed description, see text. Abbreviations: cg, cement gland; nep, anterior neuropore. For additional abbreviations, see Fig. 1.