|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
isl1
|
|
laevis
|
NF stage 13
|
cement gland primordium
|
isl1
|
|
laevis
|
NF stage 15
|
cement gland primordium
,
mesoderm
,
cardiac mesoderm
,
profundus ganglion
,
anterior
|
isl1
|
|
laevis
|
NF stage 19
|
cement gland primordium
,
cardiac mesoderm
,
profundus ganglion
|
isl1
|
|
laevis
|
NF stage 25
|
cardiac mesoderm
,
profundus ganglion
,
trigeminal ganglion
,
facial nerve
|
isl1
|
|
laevis
|
NF stage 28
|
pineal gland
,
cardiac mesoderm
,
trigeminal ganglion
,
facial nerve
|
isl1
|
|
laevis
|
NF stage 29 and 30
|
spinal cord
,
pineal gland
,
cardiac mesoderm
,
trigeminal ganglion
,
facial nerve
|
isl1
|
|
laevis
|
NF stage 32
|
olfactory placode
,
retina
,
spinal cord
,
pineal gland
,
cardiac mesoderm
,
[+]
|
nkx2-5
|
|
laevis
|
NF stage 28
|
heart primordium
|
|
|
Fig. 2. Spatial expression pattern of Xisl-1. (A) Xisl-1 is expressed in the anteriormost region of the embryo (shown from an anterior view, dorsal is up) including the cement gland anlage (asterisk) and the cardiac crescent (arrow). (B) During early neurula stages Xisl-1 expression extends dorsally adjacent to the neural folds (cephalic placodal area) (arrows). (C) Xisl-1 mRNA additionally marks the profundal–trigeminal placodal area. (D) A parasagittal section (anterior is to the left, dorsal is up) shows the expression of Xisl-1 in the anterior mesendoderm (arrow). (E) At neural tube stages Xisl-1 transcripts are present in the cardiac crescent (arrow) and are also detected in the stomodeum abutting the cement gland on the dorsal side (arrowhead). Xisl-1 expression is maintained in the cephalic placodes and their associated ganglia at least until st. 36 (E–K and data not shown). (F) Xisl-1 is expressed in the heart region (arrow). Punctate expression is seen in precursor cells of the developing vascular system (arrowheads). (G) Xisl-1 transcripts are abundant in the foregut endoderm and pharyngeal mesoderm and expression in the heart region has become restricted to an anterior domain (arrow); arrowhead points to pineal gland. (H) Co-staining for Xisl-1 (light blue) and Nkx2.5 (dark blue) shows that Xisl-1 is expressed more anteriorly compared to Nkx2.5. (I–K) Expression of Xisl-1 in the developing heart (asterisk) decreases and becomes restricted to a dorsolateral domain. aa: aortic arches; IFT: inflow tract; lpm: lateral plate mesoderm; np: neural plate; pPrV: profundal–trigeminal placodal area; gPr: profundal ganglion; gV: trigeminal ganglion; gVII: ganglia of facial nerve VII. |