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Fig. 14. paraxis knockdown disrupts the expression of chondrogenic markers. Embryos were unilaterally injected with 10 ng of paraxisMO and processed for in situ hybridization assay. A,C,E: The loss of function of paraxis reduces the expression of chondrogenic markers pax1, pax9 and Col2a, respectively. B,D,F: Control side of embryo. A0–F0: Enlargement of A–F at the level of the black rectangle. G: Numerical summary illustrating penetrance of the loss of function of paraxis in chondrogenic markers expression. |
