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rbp1xenopus forebrain 

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Experiment details for rbp1

Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling.

Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling.

Gene Clone Species Stages Anatomy
rbp1.L laevis NF stage 21 to NF stage 22 forebrain
rbp1.L laevis NF stage 23 forebrain
rbp1.L laevis NF stage 29 and 30 forebrain

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  Figure 1. Retinol binding protein 1 expression in early embryonic development of the Xenopus. A, Anterior (St. 13, 21/22, 23) and lateral (St. 23, 30, 35) views of embryos at the indicated stages. The upper row shows embryos treated with an rbp1 antisense probe and the lower row, embryos treated with an rbp1 sense probe. Whole mount in situ hybridization experiments revealed rbp1 expression in the anterior neural tissue at stage 13 of Xenopus embryos (black arrowheads). At stages 21 to 35, rbp1 transcripts were determined in the developing eye (red arrowheads), the ventral part of the forebrain (turquois arrowhead) and the pineal gland (blue arrowhead). The dotted lines at stage 30 in A represent the levels of the sections shown in B. B, Rbp1 expression was detected in the RPE of the eye at stages 30 (left panel, transversal section, red arrowhead) and 36 (right panel, transversal section, red arrowhead) and in the anterior neural crest cells (NCCs) at stage 30 (middle panel, horizontal section). C, Expression of rbp1 compared with that of the neural crest-specific markers twist and slug. Rbp1 was detected in the lateral plate border at stage 13 and in the migrating anterior NCCs (white arrowheads) at stage 20. D, Expression of rbp1 compared with that of the eye-specific markers prox1 and rax. The first and second rows show transversal sections and the third row shows horizontal sections. Rbp1 was detected in the lens (le), the ventral part (red arrowheads) of the retina (r) and the RPE at stages 30 and 35. E, Expression of rbp1 compared with expression of rax at stage 24; both show specific expression in the ventral part of the forebrain (dotted circle, turquois arrowheads), which was also observed on sagittal sections. F, Rbp1 and rax were expressed in the pineal gland (blue arrowhead) at stage 36. G, The transcripts of rbp1 and cyp26a1 were detected in the eye at stage 30 (red arrowhead)