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rho.2xenopus eye 

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Experiment details for rho.2

Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling.

Retinol binding protein 1 affects Xenopus anterior neural development via all-trans retinoic acid signaling.

Gene Clone Species Stages Anatomy
rho.2.L laevis NF stage 42 eye

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  Figure 3. Loss of retinol binding protein 1 leads to disordered retinal layers. Transversal sections of retinol binding protein 1 (Rbp1)- or control morpholino oligonucleotide (MO)-injected embryos at stage 42. Rbp1 knockdown led to deformed and disorganized retinal layers, including rosette-like structures (close-up views) and altered retinal pigmented epithelium (RPE; red arrowheads), as shown by marker gene expression. Four of the 9 embryos showing rho expression (photoreceptor cells), 4 of the 7 embryos showing prox1 expression (horizontal cells), 5 of the 7 embryos showing vsx1 expression (bipolar cells), 6 of the 10 embryos showing pax6 expression (amacrine and ganglion cells) and 2 of the 4 embryos showing pou4f1 expression (ganglion cells) had an altered phenotype, as depicted. In contrast, the uninjected side of the embryos showed no changes of retinal lamination. Scale bar: 100 μm. Abbreviation: MO, morpholino oligonucleotide