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Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
eya1
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
somite
,
trigeminal placode
,
epibranchial placode
,
lateral line placode
|
six1
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
somite
,
otic placode
,
trigeminal placode
,
lens placode
,
[+]
|
six4
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
otic placode
,
trigeminal placode
,
epibranchial placode
,
lateral line placode
|
pax3
|
|
laevis
|
NF stage 24
to
NF stage 27
|
forebrain
,
midbrain
,
hindbrain
,
hatching gland
,
profundus ganglion
|
pax8
|
|
laevis
|
NF stage 24
to
NF stage 27
|
otic vesicle
,
pronephric mesenchyme
,
epibranchial placode
,
lateral line placode
|
pax6
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
diencephalon
,
cement gland primordium
,
lens placode
|
sox2
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
forebrain
,
midbrain
,
hindbrain
,
trigeminal placode
,
[+]
|
sox3
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
otic vesicle
,
forebrain
,
midbrain
,
hindbrain
,
[+]
|
pax2
|
|
laevis
|
NF stage 24
to
NF stage 27
|
otic vesicle
,
midbrain-hindbrain boundary
,
spinal cord
,
optic vesicle
,
pronephric mesenchyme
,
[+]
|
irx1
|
|
laevis
|
NF stage 24
to
NF stage 27
|
midbrain
,
hindbrain
,
otic placode
,
trigeminal placode
,
lens placode
,
[+]
|
msx1
|
|
laevis
|
NF stage 24
to
NF stage 27
|
otic vesicle
,
midbrain
,
hindbrain
,
optic vesicle
,
dorsal
,
[+]
|
dlx3
|
|
laevis
|
NF stage 24
to
NF stage 27
|
olfactory placode
,
otic vesicle
,
cement gland primordium
,
trigeminal placode
,
epibranchial placode
,
[+]
|
foxi4
|
|
laevis
|
NF stage 24
to
NF stage 27
|
trigeminal placode
,
lens placode
,
epibranchial placode
,
lateral line placode
|
|
|
Fig. 10. Placodal gene expression patterns in mid-tail bud Xenopus embryos (stages 24–27) in lateral views (anterior is to the left). As in Fig. 9, color-coded arrows and arrowheads are used for the identification of comparable regions of gene expression. Expression in the lens placode is indicated by L. Colors are explained in the schematic drawings, which show the distribution of placodes in stages 24 and 27 embryos (modified after Schlosser and Northcutt, 2000; see Fig. 14 for detailed explanation). By stage 24, the posterior placodal area has extended caudally, the formation of the otic vesicle by invagination of the otic placode has begun, and epibranchial placodes (orange) begin to become recognizable in its ventral part (Schlosser and Northcutt, 2000). By stage 27, the posterior placodal area has broken up into distinct placodes, while invagination of the otic vesicle is continuing (Schlosser and Northcutt, 2000). The lens placode has appeared as a focal thickening. The orange and brown double arrows indicate expression of the respective genes in a region encompassing the facial epibranchial placode and anteroventral lateral line placode, because both placodes are closely apposed and, thus, cannot be differentiated from each other. White asterisks indicate gene expression in the pharyngeal pouches (which can be clearly distinguished from placodal expression domains in transverse sections). The brown asterisk in M indicates downregulation of Pax2 in the region of the anterodorsal lateral line placode. For detailed description, see text. Abbreviations: EB, epibranchial placodes; LL, lateral line placodes; Ot, otic placode or vesicle; vba, ventral branchial arch region (all three germ layers). For additional abbreviations, see Fig. 1. |