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FIG. 6. Invasion of proteolytic enzyme expressing fibroblasts into their neighboring lamellae. (A, B) In situ hybridization of tail cross sections
with collagenase-3 antisense probe. (A) Stage 63 notochord. (B) Stage 64 notochord. (C, D) Late stage 63/early stage 64 subepidermal fibroblasts
and overlying epidermal lamella hybridized with integrin a-1 antisense probe. (C) Side muscle flank which has not yet been invaded; (D) dorsal
fin where the invasion of the epidermal lamella begins. Scale bars, 100 mm. Images in C and D were taken with Nomarski optics. |
