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Figure 1. Dystroglycan transcript and protein expressions. A-C: Lateral view, whole-mount in situ hybridization at stage 21 (A), 23 (B), and 27 (C). Dg mRNAs are detected in the dorsal region, posteriorly in the presomitic mesoderm and in the mesoderm in a series of stripes. D: Stage 40, lateral view, in toto immunodetection. The staining of the Dg protein is associated with the intersomitic junctions and the notochord (white arrow). mu m; b, brain; ov, otic vesicle; psm, presomitic mesoderm; s, somites; va, visceral arches; p, pronephros and duct. Scale bar = 400 mu m. |
