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GEO Series: GSE150911

Title: Using RNAseq for identifying hepatic genes involved in multi- (F1 generation) and transgenerational (F2 generation) responses to chronic benzo[a]pyrene exposure (F0 generation) in Xenopus tropicalis

Summary

We investigated the multi- and transgenerational impact of BaP on Xenopus females following F0 generation exposure from the tadpole to the mature adult stage at a concentration (50 ng.L-1). 5 females from F1 and F2 generations by parentale xposure conditions (control vs BaP) were used for studying liver transcriptome by RNAseq. RNA-seq libraries were sequenced on an illumina GAIIx sequencer as 75bp single reads


Contributors: Stéphane REYNAUD

Experiment Type: mRNAseq from liver of mature F1 and F2 females.

Experiment Reagents: ancestral Benzo(a)pyrene exposure.

Phenotypes:
Xtr Wt + ancestral Benzo(a)pyrene exposure + liver adult F1 generation (RNA-Seq (RNA))

Article: XB-ART-57563, PubMed

Source: NCBI GEO, Xenbase FTP

Samples: (DEG = Differentially Expressed Genes; GSM = GEO Sample Number)
Sample View GSMs Assay Type
liver - adult F1 GSM4560793  GSM4560794  GSM4560795  GSM4560796  GSM4560797  RNA-Seq
Background: Xtr.Outbred
Conditions:
Tissue Assay Stages ChIP Antibody
liver adult frog stage  
   liver + ancestral Benzo(a)pyrene exposure - adult F1 DEG GSM4560798  GSM4560799  GSM4560800  GSM4560801  GSM4560802  GSM4560803  RNA-Seq
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
environmental treatment ancestral Benzo(a)pyrene exposure NF stage 45 embryo
Conditions:
Tissue Assay Stages ChIP Antibody
liver adult frog stage  
liver - adult F2 GSM4560804  GSM4560805  GSM4560806  GSM4560807  GSM4560808  RNA-Seq
Background: Xtr.Outbred
Conditions:
Tissue Assay Stages ChIP Antibody
liver adult frog stage  
   liver + ancestral Benzo(a)pyrene exposure - adult F2 DEG GSM4560809  GSM4560810  GSM4560811  GSM4560812  GSM4560813  RNA-Seq
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
environmental treatment ancestral Benzo(a)pyrene exposure NF stage 45 embryo
Conditions:
Tissue Assay Stages ChIP Antibody
liver adult frog stage  
Select All DEG      Select All 
Xtr   
Xla 

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