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Figure 1. The discovery of channelrhodopsinsPhototaxis of the Chlamydomonas wild type strain CW2 and the channelrhodopsin-defective mutant H17.Electrophysiological recording from oocytes (in the centre, with two electrodes, left and right) allows investigation of light-induced (via light guide, below oocyte) currents, e.g. mediated by rhodopsins.Light-induced currents mediated by channelrhodopsin-2 (two illuminations for 1 s, blue bars) at −100 mV.Model of channelrhodopsin opening, following light absorption and isomerization of covalently bound retinal.
Figure 2. Cartoon of the Channelrhodopsin 7TM-fragmentThe structure is drawn according to the data of Kato et al (2012) with key residues shown in color: voltage sensor E123 (cyan), residues of the access channel (magenta), central gate (blue), and inner gate (orange), OH-cluster green, and the retinal Schiff base is seen in red.
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