Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-54799
Zoolog Sci 2018 Apr 01;352:109-114. doi: 10.2108/zs170145.
Show Gene links Show Anatomy links

Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.

Mochimaru Y , Negishi J , Murakami S , Musha S , Sato K , Okajima F , Tomura H .


???displayArticle.abstract???
Human, mouse, and zebrafish ovarian cancer G protein-coupled receptors (OGR1s) are activated by both metals and extracellular protons. In the present study, we examined whether pig, rat, chicken, and Xenopus OGR1 homologs could sense and be activated by protons and metals. We found that all homologs stimulated serum response element (SRE)-driven promoter activities when they are stimulated by protons. On the other hand, metals differentially activated the homologs. The results using chimeric receptors of human and zebrafish OGR1s indicate that the specificity of the metal-induced activation lies in the extracellular region. These results suggest that protons are an evolutionally conserved agonist of OGR1. However, the types of metals that activated the receptor differed among the homologs.

???displayArticle.pubmedLink??? 29623784
???displayArticle.link??? Zoolog Sci