XB-ART-10406Semin Cell Dev Biol August 1, 2000; 11 (4): 291-9.
Show Gene links Show Anatomy links
Assembly of tight junctions during early vertebrate development.
Tight junction formation during development is critical for embryonic patterning and organization. We consider mechanisms of junction biogenesis in cleaving mouse and Xenopus eggs. Junction assembly follows the establishment of cell polarity at 8-cell (mouse) or 2-cell (Xenopus) stages, characterized by sequential membrane delivery of constituents, coordinated by embryonic (mouse) or maternal (Xenopus) expression programmes. Cadherin adhesion is permissive for tight junction construction only in the mouse. Occludin post-translational modification and membrane delivery, mediated by delayed ZO-1 alpha(+)isoform expression in the mouse, provides a mechanism for completion of tight junction biogenesis and sealing, regulating the timing of blastocoel cavitation.
PubMed ID: 10966863
Article link: Semin Cell Dev Biol
Species referenced: Xenopus
Genes referenced: ocln