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Mech Dev July 1, 2000; 95 (1-2): 279-82.

Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-beta superfamily, is expressed in the hindbrain and epibranchial placodes.

We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon.

PubMed ID: 10906478
Article link: Mech Dev
Grant support: [+]

Species referenced: Xenopus
Genes referenced: gdf7 tgfb1

Article Images: [+] show captions