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J Anat February 1, 2000; 196 ( Pt 2) 249-61.

Characterisation of Kupffer cells in some Amphibia.

Corsaro C , Scalia M , Leotta N , Mondio F , Sichel G .

A study on the Kupffer cells (KCs) of Amphibia was undertaken in order to compare these cells with those of endothermic animals. Liver tissue and isolated and cultured KCs were studied by light microscopy and by transmission and scanning electron microscopy. We have shown that amphibian KCs can be divided into 2 principal types: ''small'' and ''large''. Both cell types possess the distinctive KC morphology. They show nonspecific esterase activity, weak endogenous peroxidase activity in the nuclear envelope and in the rough endoplasmic reticulum, and the ability to engulf naturally present cell debris or experimentally administered zymosan or latex particles. The principal difference between the small and the large cells consists in the substantial quantity of inclusion bodies that exist only in the latter. We conclude that amphibian KCs, apart from their ability to build melanosomes and synthesise melanins, are very similar to mammalian KCs.

PubMed ID: 10739021
PMC ID: PMC1468058
Article link: J Anat

Species referenced: Xenopus
Genes referenced: ces3.4

References [+] :
Armbrust, Functional characterization of two different Kupffer cell populations of normal rat liver. 1997, Pubmed