Johnson KG and Holt CE (2000), Expression of CRYP-alpha, LAR, PTP-delta, and P...

XB-ART-11318

Mech Dev 2000 Apr 01;922:291-4. doi: 10.1016/s0925-4773(99)00345-7.

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Expression of CRYP-alpha, LAR, PTP-delta, and PTP-rho in the developing Xenopus visual system.

Johnson KG , Holt CE .

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Receptor protein tyrosine phosphatases (RPTPs), are involved in axon outgrowth and guidance not only in the Drosophila visual system (Garrity et al., 1999. Neuron 22, 707-717) but also in the developing vertebrate retina (Ledig et al., 1999a. J. Cell Biol. 147, 375-388). We have cloned a variety of Xenopus RPTPs, including four RPTPs expressed in the developing visual system (LAR, PTP-delta, CRYP-alpha and PTP-rho). These four RPTPs are transcribed in the developing optic vesicle during differentiation and in overlapping but distinct patterns in the developing retina during retinal layer formation. LAR, PTP-delta, and CRYP-alpha are also expressed in retinal ganglion cells during axonogenesis and during axon guidance from the retina to the optic tectum.

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Species referenced: Xenopus
Genes referenced: ptprd ptprf ptprs ptprt ptpru rho tbx2 tgm2

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	Fig. 2. Whole-mount in situ hybridizations using antisense DIG-labeled mRNA probes for CRYP-α, LAR, PTP-δ, and PTP-ρ in the developing albino Xenopus embryo at stages 19 (A,D,G,J); 24 (E,H)–25 (B,K); and stages 28 (C,F,L)–29/30 (I). For the stage-19 embryos, anterior is up (dorsal view). For all other embryos, anterior is right and dorsal is up. OV, optic vesicle; LPM, lateral plate mesoderm; S, somite; TGC, trigeminal complex; N, notochord; SC, spinal cord; Hb, hindbrain; Mb, midbrain; Fb, forebrain; NT, neural tube.
	Fig. 3. In situ hybridizations using antisense DIG-labeled mRNA probes for CRYP-α, LAR, PTP-δ, and PTP-ρ on 15-μm paraffin-sectioned pigmented Xenopus retinae at stages 35/36, 39 and 41. Sections are near the retinal midline, and dorsal is up. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer.
	ptprs (protein tyrosine phosphatase receptor type S) gene expression in X. laevis, NF stage 28,asayed via in situ hybridization, lateral view, anterior right, dorsal up. Key: N=notochord; SC= spinal cord; Hb= hindbrain; Mb= midbrain; Fb= forebrain; TGc= trigeminal ganglion; S= somites., Eye=eye.