XB-ART-11483
Curr Opin Cell Biol
2000 Feb 01;121:52-6. doi: 10.1016/s0955-0674(99)00056-3.
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Microtubule dynamics and tubulin interacting proteins.
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Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op 18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.
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Species referenced: Xenopus
Genes referenced: kif2c stmn1