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Development January 1, 2000; 127 (2): 425-35.

Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins.

Bao J , Talmage DA , Role LW , Gautier J .

Basic-helix-loop-helix transcription factors regulate neurogenesis and neuronal differentiation by as yet unknown mechanisms. We show that an embryonic neuronal-specific basic-helix-loop-helix protein, HEN1 (also known as NSCL1 or NHLH), interacts with ''LIM only'' proteins. Examination of the expression patterns of XHEN1 and XLMO-3, the Xenopus homologues of these human genes, reveals extensive overlap during early neurogenesis: at the onset of gastrulation on the dorsal side of the blastopore lip and, subsequently, in the prospective neural plate. Binding of XLMO-3 increases the transcriptional activity of XHEN1 in vivo. Co-expression of these two genes in Xenopus embryos induces a cascade of expression of neuronal-specific basic-helix-loop-helix proteins that leads to neuronal differentiation. We propose that XHEN1, in concert with XLMO-3, is a critical regulator of neurogenesis.

PubMed ID: 10603358
Article link: Development
Grant support: [+]

Species referenced: Xenopus
Genes referenced: acta4 actc1 fos kit lmo1 lmo3 mespa myc neurod1 neurod6 neurog2 nhlh1 pnma2 tubb2b
Antibodies: Neuronal Ab2

Article Images: [+] show captions