Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Proc Natl Acad Sci U S A
1999 Dec 07;9625:14366-71. doi: 10.1073/pnas.96.25.14366.
Show Gene links
Show Anatomy links
Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae.
Sarkar S
,
Azad AK
,
Hopper AK
.
???displayArticle.abstract???
Nuclear tRNA aminoacylation was proposed to provide a proofreading step in Xenopus oocytes, ensuring nuclear export of functional tRNAs [Lund, E. & Dahlberg, J. E. (1998) Science 282, 2082-2085]. Herein, it is documented that tRNA aminoacylation also occurs in yeast nuclei and is important for tRNA export. We propose that tRNA aminoacylation functions in one of at least two parallel paths of tRNA export in yeast. Alteration of one aminoacyl-tRNA synthetase affects export of only cognate tRNA, whereas alterations of two other aminoacyl-tRNA synthetases affect export of both cognate and noncognate tRNAs. Saturation of tRNA export pathway is a possible explanation of this phenomenon.
Aebi,
Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae.
1990, Pubmed
Aebi,
Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae.
1990,
Pubmed
Arts,
Identification of a nuclear export receptor for tRNA.
1998,
Pubmed
,
Xenbase
Arts,
The role of exportin-t in selective nuclear export of mature tRNAs.
1998,
Pubmed
,
Xenbase
Görlich,
A novel class of RanGTP binding proteins.
1997,
Pubmed
,
Xenbase
Hartwell,
Mutants of yeast with temperature-sensitive isoleucyl-tRNA synthetases.
1968,
Pubmed
Hartwell,
A mutant of yeast apparently defective in the initiation of protein synthesis.
1969,
Pubmed
Hellmuth,
Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.
1998,
Pubmed
Hentzen,
Relation between aminoacyl-tRNA stability and the fixed amino acid.
1972,
Pubmed
Hopper,
A yeast mutant which accumulates precursor tRNAs.
1978,
Pubmed
Hopper,
Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs.
1980,
Pubmed
Hurt,
Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing.
1987,
Pubmed
Izaurralde,
Transport of macromolecules between the nucleus and the cytoplasm.
1998,
Pubmed
Jarmolowski,
Nuclear export of different classes of RNA is mediated by specific factors.
1994,
Pubmed
,
Xenbase
Keith,
[Optimal conditions of aminoacylation of yeast tRNA Asp and tRNA Trp].
1971,
Pubmed
Kerjan,
The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals.
1994,
Pubmed
Kuo,
Cloning of Saccharomyces cerevisiae DNA replication genes: isolation of the CDC8 gene and two genes that compensate for the cdc8-1 mutation.
1983,
Pubmed
Kutay,
Identification of a tRNA-specific nuclear export receptor.
1998,
Pubmed
,
Xenbase
Lipowsky,
Coordination of tRNA nuclear export with processing of tRNA.
1999,
Pubmed
,
Xenbase
Lund,
Proofreading and aminoacylation of tRNAs before export from the nucleus.
1998,
Pubmed
,
Xenbase
McLaughlin,
A mutant of yeast with a defective methionyl-tRNA synthetase.
1969,
Pubmed
Mirande,
Aminoacyl-tRNA synthetase family from prokaryotes and eukaryotes: structural domains and their implications.
1991,
Pubmed
Ohno,
Nucleocytoplasmic transport: the last 200 nanometers.
1998,
Pubmed
Percudani,
Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae.
1997,
Pubmed
Sarkar,
tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysis.
1998,
Pubmed
Schimmel,
Getting tRNA synthetases into the nucleus.
1999,
Pubmed
,
Xenbase
Simos,
The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.
1996,
Pubmed
Simos,
Transfer RNA biogenesis: A visa to leave the nucleus.
1999,
Pubmed
Simos,
Nuclear pore proteins are involved in the biogenesis of functional tRNA.
1996,
Pubmed
Varshney,
Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase.
1991,
Pubmed
Vijayraghavan,
Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.
1989,
Pubmed
Wang,
Isolation of a yeast gene involved in species-specific pre-tRNA processing.
1988,
Pubmed
Weis,
Importins and exportins: how to get in and out of the nucleus.
1998,
Pubmed
Wente,
A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.
1993,
Pubmed
Wolfe,
Mechanisms leading to and the consequences of altering the normal distribution of ATP(CTP):tRNA nucleotidyltransferase in yeast.
1996,
Pubmed
Zasloff,
tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process.
1983,
Pubmed
,
Xenbase
