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XB-ART-12001
Science 1999 Nov 12;2865443:1365-7.
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Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk.

Gross SD , Schwab MS , Lewellyn AL , Maller JL .


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Before fertilization, vertebrate eggs are arrested in metaphase of meiosis II by cytostatic factor (CSF), an activity that requires activation of the mitogen-activated protein kinase (MAPK) pathway. To investigate whether CSF arrest is mediated by the protein kinase p90Rsk, which is phosphorylated and activated by MAPK, a constitutively activated (CA) form of Rsk was expressed in Xenopus embryos. Expression of CA Rsk resulted in cleavage arrest, and cytological analysis showed that arrested blastomeres were in M phase with prominent spindles characteristic of meiotic metaphase. Thus, Rsk appears to be the mediator of MAPK-dependent CSF arrest in vertebrate unfertilized eggs.

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Species referenced: Xenopus
Genes referenced: mapk1 rps6ka1

References :
Nebreda, Perspectives: signal transduction. Cell survival demands some Rsk. 1999, Pubmed